We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Exertional Desaturation as a Predictor of Rapid Lung Function Decline in COPD.
- Authors
Kim, Changhwan; Seo, Joon Beom; Lee, Sang Min; Lee, Jae Seung; Huh, Jin Won; Lee, Jin Hwa; Ra, Seung Won; Lee, Ji-Hyun; Kim, Eun-Kyung; Kim, Tae-Hyung; Kim, Woo Jin; Lee, Sang-Min; Lee, Sang Yeub; Lim, Seong Yong; Shin, Tae Rim; Yoon, Ho Il; Sheen, Seung Soo; Oh, Yeon-Mok; Park, Yong Bum; Lee, Sang-Do
- Abstract
Background: To date, no clinical parameter has been associated with the decline in lung function other than emphysema severity in COPD. Objectives: The main purpose of this study was to explore whether the rate of lung function decline differs between COPD patients with and without exertional desaturation. Methods: A total of 224 subjects were selected from the Korean Obstructive Lung Disease cohort. Exertional desaturation was assessed using the 6-min walk test (6MWT), and defined as a post-exercise oxygen saturation (SpO2) of <90% or a ≥4% decrease. The cohort was divided into desaturator (n = 47) and non-desaturator (n = 177) groups. Results: There was a significant difference between the desaturator and non-desaturator groups in terms of the change in pre-bronchodilator forced expiratory volume in 1 s (FEV1) over a 3-year period of follow-up (p = 0.006). The mean rate of decline in FEV1 was greater in the desaturator group (33.8 ml/year) than in the non-desaturator group (11.6 ml/year). A statistically significant difference was also observed between the two groups in terms of the change in the St. George's Respiratory Questionnaire (SGRQ) total score over 3 years (p = 0.001). Conclusions: This study suggests, for the first time, that exertional desaturation may be a predictor of rapid decline in lung function in patients with COPD. The 6MWT may be a useful test to predict a rapid lung function decline in COPD. Copyright © 2012 S. Karger AG, Basel
- Subjects
KOREA; ACTIVE oxygen in the body; ANALYSIS of variance; CONFIDENCE intervals; STATISTICAL correlation; PULMONARY emphysema; LONGITUDINAL method; OBSTRUCTIVE lung diseases; MEDICAL cooperation; QUALITY of life; QUESTIONNAIRES; RESEARCH; RESEARCH funding; RESPIRATORY measurements; PULMONARY function tests; SPIROMETRY; T-test (Statistics); TOMOGRAPHY; U-statistics; LOGISTIC regression analysis; VITAL capacity (Respiration); SEVERITY of illness index; DISEASE exacerbation; DATA analysis software; DESCRIPTIVE statistics; EXERCISE tolerance
- Publication
Respiration, 2013, Vol 86, Issue 2, p109
- ISSN
0025-7931
- Publication type
Article
- DOI
10.1159/000342891