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- Title
Long-Term Treatment with Infliximab in Patients with Sarcoidosis.
- Authors
Hostettler, Katrin E.; Studler, Ueli; Tamm, Michael; Brutsche, Martin H.
- Abstract
Background: Long-term benefit and safety of infliximab treatment in patients with chronic sarcoidosis remain unclear. Objectives: It was the aim of this study to assess the clinical benefit and safety of long-term infliximab treatment in patients with chronic steroid-resistant sarcoidosis. Methods: We conducted a retrospective chart review of all patients with chronic steroid-resistant sarcoidosis who received infliximab between January 2003 and November 2010. Pulmonary function tests and index lesions before and after infliximab therapy were assessed. Results: Between January 2003 and November 2010, 28 patients received in-fliximab, 16 of them for more than 12 months. Five (31%) of these 16 patients with long-term infliximab treatment had a predominantly pulmonary disease, whereas 11 (69%) had a predominantly extrapulmonary involvement. Mean duration of treatment for the 16 patients was 29 months (range 12-62). Six of 11 (55%) patients with mainly extrapulmonary sarcoidosis showed a complete remission of their index lesion, 4/11 (36%) had a partial remission and 1/11 (9%) showed no response. One out of 5 patients with predominantly pulmonary sarcoidosis showed a >10% improvement in percentage predicted forced vital capacity, 3/5 showed a 0-10% improvement, and in 1/5 patients, percentage predicted forced vital capacity declined during infliximab treatment. Thus, overall, 14/16 (88%) patients profited from long-term infliximab treatment. Suspected adverse effects which lead to a temporary withdrawal of infliximab therapy were noticed in 1/16 (6%) patients. Conclusions: This retrospective study indicates that long-term infliximab is very efficient and safe in patients with chronic steroid-resistant sarcoidosis when assessed with individualized treatment targets. Patients with predominantly extrapulmonary sarcoidosis seem to profit more than patients with a predominantly pulmonary disease. Copyright © 2011 S. Karger AG, Basel
- Subjects
SWITZERLAND; ADRENOCORTICAL hormones; BRADYCARDIA; INTERDISCIPLINARY research; MAGNETIC resonance imaging; PULMONARY function tests; RESEARCH funding; SARCOIDOSIS; INFLIXIMAB; RETROSPECTIVE studies; DESCRIPTIVE statistics
- Publication
Respiration, 2012, Vol 83, Issue 3, p218
- ISSN
0025-7931
- Publication type
Article
- DOI
10.1159/000328738