We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A penalized algorithm for event-specific rate models for recurrent events.
- Authors
BOUAZIZ, O.; GUILLOUX, A.
- Abstract
We introduce a covariate-specific total variation penalty in two semiparametric models for the rate function of recurrent event process. The two models are a stratified Cox model, introduced in Prentice and others (1981. On the regression analysis of multivariate failure time data. Biometrika 68, 373-379. ), and a stratified Aalen's additive model. We show the consistency and asymptotic normality of our penalized estimators. We demonstrate, through a simulation study, that our estimators outperform classical estimators for small-to-moderate sample sizes. Finally, an application to the bladder tumor data of Byar (1980. The veterans administration study of chemoprophylaxis for recurrent stage 1 bladder tumors: comparison of placebo, pyridoxine, and topical thiotepa. In Pavone-Macaluso,M. Smith, P. H. and F. Edsmyn (editors), Bladder Tumors and Others Topics in Urological Oncology, pp. 363-370. ) is presented.
- Subjects
MULTIVARIATE analysis; ALGORITHMS; DISEASE relapse; REGRESSION analysis; CHEMOPREVENTION; BLADDER tumors
- Publication
Biostatistics, 2015, Vol 16, Issue 2, p281
- ISSN
1465-4644
- Publication type
Article
- DOI
10.1093/biostatistics/kxu046