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- Title
Interim analyses using repeated confidence bands.
- Authors
Hu, X. Joan; Lagakos, Stephen W.
- Abstract
Clinical trials often include interim analyses that compare treatment groups with respect to the mean function of a response process. Sometimes it is unclear how the mean functions of the groups might differ, and thus one cannot confidently prespecify a simple metric upon which a stopping rule or repeated confidence interval can be based. This motivated us to extend the repeated confidence intervals approach for a finite-dimensional parameter (Jennison & Turnbull, 1989) to the use of repeated confidence bands for the mean function of a response process. Formal tests of hypotheses are easily constructed from the repeated confidence bands. We also describe how inferences for the mean function can be adaptively restricted to different subsets of its domain at different interim analyses. An example is given involving an AIDS clinical trial.
- Subjects
STATISTICAL hypothesis testing; CLINICAL trials; PARAMETERS (Statistics); THERAPEUTICS; AIDS research
- Publication
Biometrika, 1999, Vol 86, Issue 3, p517
- ISSN
0006-3444
- Publication type
Article