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- Title
ABO-Incompatible Living Kidney Transplant Recipients from Spousal Donors Receiving Rituximab.
- Authors
Uchida, Junji; Iwai, Tomoaki; Kabei, Kazuya; Nishide, Shunji; Yamasaki, Takeshi; Kuwabara, Nobuyuki; Naganuma, Toshihide; Kumada, Norihiko; Takemoto, Yoshiaki; Nakatanti, Tatsuya
- Abstract
Introduction: We summarized our experience with ABO-incompatible living kidney transplant recipients from spousal donors receiving rituximab. Patients and Methods: Between June 2006 and December 2014, 82 patients with end-stage renal disease underwent living donor kidney transplantation at Osaka City University Hospital, of which 23 cases were ABO-incompatible transplantation between spouses with rituximab induction. We analyzed these recipients, focusing on their immunosuppressive protocols, frequency of acute rejections, and patient/graft survivals. Results: Patient and graft survival rates were 100%. The incidence of acute cellular rejection (ACR) was 30.4%. One patient experienced antibody-mediated rejection (AMR) and intractable ACR, 2 had AMR, and 2 had intractable ACR episodes that were treated using thymoglobulin. Conclusions: This study demonstrated that ABO-incompatible kidney transplantation between spouses using rituximab is a radical but effective treatment for end-stage renal disease. However, this procedure could be immunologically high risk due to ABO-incompatibility and poor histocompatibility.
- Subjects
ABO blood group system; KIDNEY transplant patients; ORGAN donors; RITUXIMAB; HISTOCOMPATIBILITY; IMMUNOSUPPRESSIVE agents
- Publication
Urologia Internationalis, 2016, Vol 97, Issue 4, p457
- ISSN
0042-1138
- Publication type
Article
- DOI
10.1159/000449014