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- Title
Phase I Study of L-Asparaginase (NSC 109229).
- Authors
Wilson, W.L.; Weiss, A.J.; Ramirez, G.
- Abstract
22 patients received intravenously infused L-asparaginase (Escherichia coli) on a protocol for 5 weekly doses. 13 patients received 100 U/kg, 1 patient 500 U/kg, and 8 patients 1,500 U/kg. Only 3 of the 9 patients receiving 500 U/kg or more were able to complete the 5-week protocol. 11 of the 13 patients receiving 100 U/kg were able to complete the 5-week protocol. Significant tumor responses were not seen. CNS toxicity and allergic reactions were observed at high- and low-dose levels. There was no difference as to the degree of protein changes, BUN elevation, or liver function abnormalities at the different dose levels. Copyright © 1975 S. Karger AG, Basel
- Publication
Oncology, 1975, Vol 32, Issue 3/4, p109
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000225057