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- Title
OPINION: The phosphatidylserine receptor: a crucial molecular switch?
- Authors
Henson, Peter M.; Bratton, Donna L.; Fadok, Valerie A.
- Abstract
The uptake and removal of necrotic or lysed cells involves inflammation and an immune response, due in part to processes that involve members of the collectin family, surface calreticulin and CD91. Clearance of apoptotic cells, by contrast, does not induce either inflammation or immunity. Could the phosphatidylserine receptor be the molecular switch that determines what the outcome will be?
- Subjects
PHOSPHATIDYLSERINES; PHOSPHOLIPIDS; NOOTROPIC agents; CELL receptors; CELL physiology
- Publication
Nature Reviews Molecular Cell Biology, 2001, Vol 2, Issue 8, p627
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/35085094