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- Title
Immune regulation: TSLP: not just skin deep.
- Authors
Allan, Sarah
- Abstract
The article reports on the study of B-cell lympho-proliferative disease in newborn mice in the connection of skin-barrier defects. The authors used the induction of thymic stromal lymphopoietin (TLSP) expression by skin keratinocytes in the identification of early death of mutant mice. This results to TLSP-mediated B-cell proliferation and may shows skin-barrier defects. Meanwhile, the study clarifies the capacity of skin disruption to influence systematic immune responses.
- Subjects
B cells; LYMPHOCYTES; LABORATORY mice; SKIN diseases; THYMIC hormones; KERATINOCYTES; IMMUNE response; DISEASES
- Publication
Nature Reviews Immunology, 2008, Vol 8, Issue 7, p492
- ISSN
1474-1733
- Publication type
Article
- DOI
10.1038/nri2363