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- Title
TFIIH: when transcription met DNA repair.
- Authors
Compe, Emmanuel; Egly, Jean-Marc
- Abstract
The transcription initiation factor TFIIH is a remarkable protein complex that has a fundamental role in the transcription of protein-coding genes as well as during the DNA nucleotide excision repair pathway. The detailed understanding of how TFIIH functions to coordinate these two processes is also providing an explanation for the phenotypes observed in patients who bear mutations in some of the TFIIH subunits. In this way, studies of TFIIH have revealed tight molecular connections between transcription and DNA repair and have helped to define the concept of 'transcription diseases'.
- Subjects
DNA repair; NUCLEOTIDES; GENETIC transcription; GENETIC code; SURGICAL excision; PHENOTYPES
- Publication
Nature Reviews Molecular Cell Biology, 2012, Vol 13, Issue 6, p343
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm3350