The article discusses research being done on chromatin. It references the study "Chromatin signaling to kinetochores:kinetochores: transregulation of Dam1 methylation by histone H2B ubiquitination" by J. A. Latham and colleagues in the issue of "Cell." Moreover, the study reveals that histone modifications can directly affect the methylation of non-histone proteins with essential consenquences for chromosome segregation.