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- Title
Role of bone marrow-derived mesenchymal stem cells in the prevention of hyperoxia-induced lung injury in newborn mice.
- Authors
Zhang, Xiaoying; Wang, Hui; Shi, Yun; Peng, Wei; Zhang, Sheng; Zhang, Wanqiao; Xu, Jing; Mei, Yabo; Feng, Zhichun
- Abstract
BPD (bronchopulmonary dysplasia) is predominantly characterized by persistent abnormalities in lung structure and arrested lung development, but therapy can be palliative. While promising, the use of BMSC (bone marrow-derived mesenchymal stem cell) in the treatment of lung diseases remains controversial. We have assessed the therapeutic effects of BMSC in vitro and in vivo. In vitro co-culturing with injured lung tissue increased the migration-potential of BMSC; and SP-C (surfactant protein-C), a specific marker of AEC2 (type II alveolar epithelial cells), was expressed. Following intraperitoneal injection of BMSC into experimental BPD mice on post-natal day 7, it was found that BMSC can home to the injured lung, express SP-C, improve pulmonary architecture, attenuate pulmonary fibrosis and increase the survival rate of BPD mice. This work supports the notion that BMSC are of therapeutic benefit through the production of soluble factors at bioactive levels that regulate the pathogenesis of inflammation and fibrosis following hyperoxia.
- Subjects
LUNG injury prevention; MESENCHYMAL stem cells; HYPEROXIA; LABORATORY mice; PULMONARY surfactant-associated protein C; FIBROSIS
- Publication
Cell Biology International, 2012, Vol 36, Issue 6, p589
- ISSN
1065-6995
- Publication type
Article
- DOI
10.1042/CBI20110447