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- Title
Verbal fluency of patients with paranoid schizophrenia, first grade schizophrenia relatives and healthy controls - comparative study.
- Authors
Stoimenova-Popova, M.; Veleva, I.; Chumpalova, P.; Tumbev, L.; Yakimova, R.; Dimitrova, E.; Krasteva, E.; Valkova, M.
- Abstract
Introduction: Schizophrenia is considered to be neurobiological disease with basic neurocognitive deficit. Cognitive impairments are a key symptom of the disease and are associated with the hypothesis of impaired neurodevelopment due to schizophrenia. The impairments in the verbal fluency (VF) are referred to the earliest indicators for cognitive deficit. Objectives: The aim of our study was to compare VF performances between patients with paranoid schizophrenia (PS), first grade relatives (FGR) and healthy controls (HC). Methods: The research was carried out on 108 patients with PS, 58 FGR and 60 HC via Isaack's Set Test (IST) for semantic and test for literal fluency (LF) type K-A-M-E. Results: The average results in the patients for IST is 28.59 words. The FGR generate an average of 32.91 words, and the HC - 34.38 words (p>0.005). In relation to the LF the data show that PS have generated on average 18.05 words, the FGR generate on average 21.66 words, and the HC on average 23.25 words (p= 0.0021). Patients with PS have lower results on IST and LVF than FGR and HC, they show also qualitative changes, while the FGR and the HC distinguish only on LF. Ageing, formal education, duration and severity of the disease, negative symptoms and symptoms of disorganization are associated with tests performances. Conclusions: Severity of PS and particularly positive and negative syndromes, is associated with VF deficit. FGR also show low LF. These deficits are probably due to primary executive dysfunctions associated with neurodevelopment changes.
- Subjects
PEOPLE with schizophrenia; SCHIZOPHRENIA; SYMPTOMS; COGNITION disorders; DISEASE duration
- Publication
European Psychiatry, 2020, Vol 63, pS23
- ISSN
0924-9338
- Publication type
Article