We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Modulation of hippocampal functional connectivity and depressive symptom improvement following ECT.
- Authors
Takamiya, A.; Kishimoto, T.; Hirano, J.; Nakajima, K.; Katayama, N.; Kikuchi, T.; Yamagata, B.; Nakagawa, A.; Mimura, M.
- Abstract
Introduction: Electroconvulsive therapy (ECT) is the most effective treatment for severe depression. Compared to a wealth of evidence about ECT-induced hippocampal volume increase, little is known about the effect of ECT on hippocampal functional connectivity (FC) and its association with clinical effect of ECT. Objectives: To test whether the hippocampal FC changes induced by ECT were associated with clinical improvement. Methods: Resting-state functional MRI (rs-fMRI) was acquired before and after bilateral ECT in depressed individuals. A priori hippocampal seed-based FC analysis was conducted to investigate FC changes associated with clinical improvement. Depressive symptoms were evaluated using the 17-item Hamilton Depression Rating Scale (HAM-D). The analysis was conducted in the CONN toolbox, including seed-to-voxel maps as seeds, time as between-conditions contrast, and percentage change in HAM-D as between-subjects contrast. Age, sex, and baseline HAM-D scores were included as nuisance covariates. The statistical threshold was set at cluster-level false discovery rate (FDR)-corrected p <0.05 with a voxel height of p <0.001. Results: Twenty-seven depressed individuals (67.5 ± 8.1 years old; 19 female) participated in the study. Connectivity changes between the right hippocampus and one cluster located in the ventromedial prefrontal cortex (vmPFC) showed positive correlation with HAMD changes. Connectivity changes of the left hippocampal seed did not show any correlations with HAM-D changes. Conclusions: Depressive symptom improvement after ECT was associated with right hippocampus-vmPFC connectivity changes. Given previous studies investigating other antidepressant treatments, modulation of the right frontolimbic connectivity may be critical for recovery from depression regardless of treatment modality.
- Subjects
FUNCTIONAL connectivity; MENTAL depression; HAMILTON Depression Inventory; HIPPOCAMPUS (Brain); ELECTROCONVULSIVE therapy
- Publication
European Psychiatry, 2020, Vol 63, pS373
- ISSN
0924-9338
- Publication type
Article