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- Title
Investigation of NF-εB Gene Polymorphisms in Individuals Infected with COVID-19 Virus.
- Authors
Şahin, Nil Özbilüm; Bayyurt, Burcu; Baltacı, Sevgi; Arslan, Serdal; Bakır, Mehmet
- Abstract
Introduction: Coronavirus disease-2019 (COVID-19) is a disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) coronavirus that emerged in Wuhan, China. SARS-CoV-2 is an enveloped, positive-sense, single-stranded RNA virus belonging to the betacoronavirus genus. NF-κB is a family of protein transcription factors that can orchestrate many inflammatory processes. NF-κB genes have been associated with the development of many viral diseases and cancer. Therefore, this study aimed to investigate COVID-19 disease and NF-κB1-94 Ins/Del ATTG, NF-κB1A 3'UTR A/G, NF-κB1A -826 C/T polymorphisms. Methods: The patient group was composed of 150 individuals who were definitively diagnosed with COVID-19 disease by Sivas Cumhuriyet University Faculty of Medicine, Department of Infectious Diseases. Approval was received by Sivas Cumhuriyet University Clinical Research Ethics Committee (decision no: 2021-02/07). The control group consisted of 150 healthy individuals whose blood was taken during the period when there was no COVID-19 epidemic (Ethics Committee decision no: 2009-02/5). Total DNA was isolated from the blood samples taken, and then PCR-RFLP study was performed to determine polymorphisms. The data were uploaded to the SPSS (Ver: 23.0) program and the chi-square test was used for evaluation. Results:A statistically significant difference was found in the D allele distribution for the NF-κB1-94 ins/del polymorphism. Additionally, a statistically significant result was found in the WD and DD genotype distribution. For NF-κB1A 3'UTR A/G polymorphism, there was a statistically significant difference in the distribution of the G allele of patients with COVID-19. Additionally, CT and TT genotype distributions were found to be statistically significant. The T allele distribution for the NFk-B1A -826 C/T polymorphism has a statistically significant difference, and the CT and TT genotype distributions were also found to be statistically significant. Conclusion: There is a significant relationship between COVID-19 disease and NF-κB genes, but further studies are needed for this gene.
- Subjects
WUHAN (China); SARS-CoV-2; VIRUS diseases; COVID-19; COVID-19 pandemic; GENETIC polymorphisms; THEILERIA
- Publication
Gazi Medical Journal, 2024, Vol 35, p42
- ISSN
1300-056X
- Publication type
Article