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- Title
ETIOPATHOGENICAL ASPECTS OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS IN ELDERLY.
- Authors
Bursova¹, Mihaela; Lilios², Gabriela; Suta³, Maria; Taralunga², Gh.
- Abstract
Nonsteroidal anti-inflammatory (NSAIDs) induced gastritis still represent one of the most frequent medical problems, especially in elderly patients, due to its increased prevalence and also due to its increased morbidity and mortality. Although gastritis are often associated with NSAIDs, evidences about predicting factors of their development in patients taking NSAIDs are poor. In addition, the ulcerogenic potentials of the newer NSAIDs are still compared with those of more established preparations (conventional NSAIDs). The aim of this study was to identify the relationship between the type of NSAIDs and their potential to produce gastric complications and also between NSAIDs and HP infection. Altogether 172 long term NSAIDs users, aged 65 years or over, were studied. The presence of abdominal complaints, previous history of ulcers, endoscopic and histological features and Helicobacter Pylori status were all assessed . NSAIDs were classified into conventional drugs(group 1) and newer agents(group 2). Group 1 included indomethacin, diclofenac,ketoprofen, piroxicam. Group 2 included meloxicam, celecoxib, etoricoxib. As in other recent clinical trials, "at risk" patients in our study (≥65 of age, concurrently taking low-dose aspirin ) taking conventional NSAIDs had a higher incidence of gastric complications (bleedings) than those taking selective COX-2 inhibitors. The HP infection status was very important to asses , but it was possible only for 120 patients. To these patients the result were 68 HP positive and 52 HP negative. HP infection and NSAIDs are independent risk factors for chronic gastritis and no difference in terms of gastric complications was observed between these two groups. (NSAIDs users HP positive and NSAIDs users HP negative)
- Subjects
NONSTEROIDAL anti-inflammatory agents; PHARMACODYNAMICS; GASTRITIS; GASTRITIS in old age; DISEASE prevalence; EPIDEMIOLOGY; THERAPEUTICS
- Publication
Annals of the Romanian Society for Cell Biology, 2012, Vol 17, Issue 2, p202
- ISSN
2067-3019
- Publication type
Article