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- Title
GLOMERULAR LESIONS IN DIABETIC PATIENTS.
- Authors
Caraba, A.; Nariţa, Andreea; Şerban, Corina; Deak, Ingrid; Romoşan, I.
- Abstract
Diabetic nephropathy represents a major microangiopathic complication of diabetes mellitus. Its features are represented by: proteinuria, arterial hypertension and renal function decrease. But proteinuria in diabetic patients may represent non-diabetic renal disease, superimposed or not on diabetic renal lesions. The present study describes the glomerular lesions in diabetic patients with proteinuria. The study was performed on a group of 40 patients with diabetes mellitus and proteinuria. Retinoscopy, monitoring of blood pressure, proteinuria, hematuria, creatinine clearance, serum creatinine were performed in all patients. Renal biopsies were done with Tru-Cut system, using hematoxylin-eosin and periodic acid Schiff (PAS) staining. All the values were presented as mean ± standard deviation. The statistically analysis was done using Student's t-test, p < 0,05 was considered statistically significant. The group of patients consisted of 25 males and 15 females, with the mean age of 44,37 ± 7,72 years. Among them, 11 patients had type 1 diabetes mellitus and 29 patients had type 2 diabetes mellitus. Histological exam showed: pure diabetic nephropathy in 24 patients (60%), and primary glomerulonephritis in 16 patients (40%). Diabetic retinopathy was found in 28 patients (70%). The values of proteinuria, creatinine clearance, serum creatinine, blood pressure did not show significant differences between the patients with pure diabetic nephropathy and primary glomerulonephritis (p > 0,05). The value of hematuria with dysmorphic cells was significant higher in patients with primary glomerulonephritis (p < 0,001). Proteinuria in diabetic patient may represent diabetic nephropathy, or primary glomerulonephritis, requiring further investigations, including renal biopsy.
- Subjects
PEOPLE with diabetes; KIDNEY diseases; GLOMERULONEPHRITIS; PROTEINURIA; DIABETIC nephropathies; RENAL biopsy
- Publication
Annals of the Romanian Society for Cell Biology, 2011, Vol 16, Issue 1, p272
- ISSN
2067-3019
- Publication type
Article