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- Title
Mechanisms of long-term cognitive dysfunction of sepsis: from blood-borne leukocytes to glial cells.
- Authors
Michels, Monique; Steckert, Amanda; Quevedo, João; Barichello, Tatiana; Dal-Pizzol, Felipe
- Abstract
Several mechanisms are associated with brain dysfunction during sepsis; one of the most important are activation of microglia and astrocytes. Activation of glial cells induces changes in permeability of the blood-brain barrier, secretion of inflammatory cytokines, and these alterations could induce neuronal dysfunction. Furthermore, blood-borne leukocytes can also reach the brain and participate in inflammatory response. Mechanisms involved in sepsis-associated brain dysfunction were revised here, focusing in neuroinflammation and involvement of blood-borne leukocytes and glial cells in this process.
- Publication
Intensive Care Medicine Experimental, 2015, Vol 3, Issue 1, p1
- ISSN
2197-425X
- Publication type
Article
- DOI
10.1186/s40635-015-0066-x