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- Title
Epilepsy-Associated Glioneuronal Tumors.
- Authors
Kopachev, D. N.; Shishkina, L. V.; Shkatova, A. M.; Golovteev, A. L.; Troitsky, A. A.; Grinenko, O. A.; Sharkova, S. M.; Petrosyan, D. V.; Gushcha, A. O.
- Abstract
Objectives. To summarize data on the radiological and histological diagnosis of benign tumors associated with epilepsy and to provide recommendations for the surgical treatment of epilepsy in these tumors. Materials and methods. Articles from PubMed and our own clinical data were used. Results. Benign glioneuronal tumors are the second most common cause of structural drug-resistant epilepsy in adults after hippocampal sclerosis. Extremely slow growth, location in the cerebral cortex, the presence of neuronal tissue in the tumor stroma, and concomitant epilepsy are common features of these neoplasms. The difficulty of treating glioneuronal tumors lies in the combination of epileptological and neurooncological aspects. The epileptogenic zone may extend beyond the tumor, so isolated resection may not be enough to stop seizures. Conclusions. From a neurooncological point of view, glioneuronal tumors are neoplasms with a very low proliferative potential, but careful differential diagnosis against more aggressive glial tumors is required; this can be extremely difficult but can be achieved using histological and immunohistochemical approaches.
- Subjects
EPILEPSY; HIPPOCAMPAL sclerosis; BENIGN tumors; TUMORS; CEREBRAL cortex; DIFFERENTIAL diagnosis
- Publication
Neuroscience & Behavioral Physiology, 2022, Vol 52, Issue 8, p1199
- ISSN
0097-0549
- Publication type
Article
- DOI
10.1007/s11055-023-01348-1