We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
血清异常凝血酶原在肝细胞癌诊疗中的意义.
- Authors
孙玉; 张洪海; 袁春旺; 扈彩霞; 刘博君; 崔石昌; 钱智玲; 张英华; 张永宏; 郑加生
- Abstract
ObjectiveTo investigate the expression of des-γ-carboxy-prothrombin (DCP) in serum in hepatocellular carcinoma (HCC) patients and its association with tumor properties, pathology, and clinical features. MethodsA total of 80 patients who were hospitalized and treated in our hospital from January 2016 to March 2018 and were diagnosed with HCC by pathology after surgical resection were enrolled. The serum levels of DCP and alpha-fetoprotein (AFP) were measured before surgery and the correlation between them was analyzed. The association of DCP level with clinical data, imaging findings, and pathological results was analyzed. Mann-Whitney U test was used for comparison of continuous data between two groups, Kruskal-Wallis H test was used for comparison between multiple groups, and the Mann-Whitney U test was used for further comparison between two groups; the Spearman correlation analysis was performed to investigate correlation. ResultsThere was no significant correlation between the serum levels of AFP and DCP in HCC patients (r=0.141, P>0.05). In HCC patients, serum DCP level was significantly correlated with tumor diameter (r=0563, P<0.01). The HCC patients with intrahepatic multiple tumors, distant metastasis, or macrovascular or microvascular invasion had a significantly higher serum DCP level than those with intrahepatic single tumor (Z=-5484,P<0.001) or without distant metastasis (Z=-4569,P<0.001), macrovascular invasion (Z=-3713,P<0.001), or microvascular invasion (Z=-3244,P=0.001). According to the staging criteria in China, the patients with stage Ⅰ HCC had a significantly lower serum DCP level than those with stage II/III HCC (P=0.005 and P<0.001), while there was no significant difference in serum DCP level between the patients with stage II HCC and those with stage III HCC (P=0.477). The patients with Edmondson-Steiner grade II/III HCC had a significantly lower serum DCP level than those with Edmondson-Steiner grade IV HCC (P<0.001 and P=0.002), while there was no significant difference in serum DCP level between the patients with Edmondson-Steiner grade II HCC and those with Edmondson-Steiner grade III HCC (P=0.133). ConclusionIn HCC patients, serum DCP level is associated with number of tumors, tumor size, clinical stage, distant metastasis, vascular invasion, and pathological grade.
- Subjects
LIVER cancer patients; PROTHROMBIN; TUMOR treatment; ALPHA fetoproteins; SURGICAL excision; METASTASIS
- Publication
Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi, 2018, Vol 34, Issue 10, p2148
- ISSN
1001-5256
- Publication type
Article
- DOI
10.3969/j.issn.1001-5256.2018.10.017