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- Title
Risk factors of human herpesvirus 6 encephalitis/myelitis after allogeneic hematopoietic stem cell transplantation.
- Authors
Miyashita, Naohiro; Endo, Tomoyuki; Onozawa, Masahiro; Hashimoto, Daigo; Kondo, Takeshi; Fujimoto, Katsuya; Kahata, Kaoru; Sugita, Junichi; Goto, Hideki; Matsukawa, Toshihiro; Hashino, Satoshi; Teshima, Takanori
- Abstract
Background Human herpesvirus 6 ( HHV-6) encephalitis/myelitis is now a well-known complication after allogeneic stem cell transplantation (allo- HSCT), particularly after cord blood transplantation ( CBT). In this study, we evaluated the risk factors of HHV-6 encephalitis/myelitis. Methods We evaluated 253 patients who received allo- HSCT from 2007 to 2015 at our institute. HHV-6 encephalitis/myelitis was defined as HHV-6 DNA detection in the cerebrospinal fluid or peripheral blood by polymerase chain reaction in the presence of typical manifestations without other concurrent condition that led to the manifestations. Results HHV-6 encephalitis/myelitis occurred in 11 patients (4.5%) (9 encephalitis, 3.7%; 2 myelitis, 0.8%). Multivariate analysis showed that CBT, mycophenolate mofetil ( MMF) for graft-versus-host disease prophylaxis, history of allogeneic hematopoietic stem cell transplantation (allo- HSCT), and engraftment syndrome ( ES) were significantly associated with incidence of HHV-6 encephalitis/myelitis ( P=.025, P=.017, P=.017, and P=.014, respectively). Conclusion Although it has been shown that CBT, ES, and history of allo- HSCT are risk factors for HHV-6 encephalitis/myelitis, our study demonstrated MMF is also a risk factor for the disease.
- Subjects
HUMAN herpesvirus-6 infections; MYELITIS; ENCEPHALITIS; HOMOGRAFTS; HEMATOPOIETIC stem cell transplantation; DISEASE risk factors; PATIENTS; INFECTIOUS disease transmission
- Publication
Transplant Infectious Disease, 2017, Vol 19, Issue 3, pn/a
- ISSN
1398-2273
- Publication type
Article
- DOI
10.1111/tid.12682