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- Title
Bifidobacterium bifidum-mediated Changes in Gastrointestinal Tight Junctions: A Review on Possible Underlying Mechanism of Lapatinib-induced Diarrhoea.
- Authors
Hisham, Nur Syafina; Khan, Jesmine; Hamid Hasani, Narimah Abdul; Yehya Talib, Hassanain Issam; I’zzah Wan Mohamad Zain, Wan Nor
- Abstract
Introduction: Lapatinib, a drug targeting ErbB1 and ErbB2 receptor tyrosine kinases, has demonstrated effectiveness in treating ErbB2-positive breast cancer. Despite its efficacy, a notable side effect associated with lapatinib is diarrhoea. Given the prolonged duration of lapatinib treatment, this side effect can significantly impact the quality of life for cancer patients. Previous studies have indicated a decrease in Bifidobacterium spp. in tyrosine kinase inhibitor (TKI)-treated patients with diarrhoea, hinting at altered microbial composition, though the precise mechanisms remain unclear. This study aims to gather updated information about Bifidobacterium bifidum (BB) altering tight junctions in gastrointestinal which could be the underlying mechanism of lapatinib-induced diarrhoea. Methods: Scopus and Pubmed were searched using the keywords Bifidobacterium bifidum combined with lapatinib, diarrhoea, intestinal permeability and tight junction proteins from 2018 to 2023. Results: Out of 191 studies, this review selectively discusses 47 articles from Scopus and 30 out of 59 articles from Pubmed. Overall, the studies highlight the significance of Bifidobacterium spp., Gram-positive anaerobes essential for maintaining intestinal homeostasis. Notably, Bifidobacterium bifidum plays diverse roles such as regulating the immune system, producing antimicrobials, modulating intestinal flora, and enhancing barrier function. Therefore, alterations in Bifidobacterium bifidum induced by lapatinib may influence tight junctions, increasing intestinal permeability and potentially leading to diarrhoea. In several studies, Caco-2 cells were used to elucidate the effect of bacterial exposure and alteration of tight junctions in the gastrointestinal tract due to their ability to spontaneously differentiate into polarised monolayers. Conclusion: This review provides an outline of the involvement of intestinal barrier, gut microflora and an appropriate in vitro model to investigate possible changes induced by lapatinib treatment. Understanding changes that occur in intestinal epithelium following lapatinib treatment will lead to targeted prevention or treatment, enabling effective management of TKI-induced diarrhoea.
- Subjects
TIGHT junctions; INTESTINAL barrier function; BIFIDOBACTERIUM bifidum; DIARRHEA; BIFIDOBACTERIUM
- Publication
Malaysian Journal of Medicine & Health Sciences, 2024, Vol 20, p55
- ISSN
1675-8544
- Publication type
Article