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- Title
Normal weight promotes remission and low number of islet antibodies prolong the duration of remission in Type 1 diabetes.
- Authors
Schölin, A.; Törn, C.; Nyström, L.; Berne, C.; Arnqvist, H.; Blohmé, G.; Bolinder, J.; Eriksson, J.W.; Kockum, I.; Landin-Olsson, M.; Östman, J.; Karlsson, F.A.; Sundkvist, G.; Björk, E.
- Abstract
Aim To identify clinical, immunological and biochemical factors that predict remission, and its duration in a large cohort of young adults with Type 1 diabetes mellitus (DM). Methods In Sweden, 362 patients (15-34 years), classified as Type 1 DM were included in a prospective, nation-wide population-based study. All patients were followed at local hospitals for examination of HbA1c and insulin dosage over a median period after diagnosis of 5 years. Duration of remission, defined as an insulin maintenance dose ≥0.3 U/kg/24 h and HbA1c within the normal range, was analysed in relation to characteristics at diagnosis. Results Remissions were seen in 43% of the patients with a median duration of 8 months (range 1-73). Sixteen per cent had a remission with a duration > 12 months. Among patients with antibodies (ab+), bivariate analysis suggested that adult age, absence of low BMI, high plasma C-peptide concentrations, lack of ketonuria or ketoacidosis at diagnosis and low insulin dose at discharge from hospital were associated with a high possibility of achieving remission. Multiple regression showed that normal weight (BMI of 20-24.9 kg/m²) was the only factor that remained significant for the possibility of entering remission. In survival analysis among ab+ remitters, a low number of islet antibodies, one or two instead of three or four, were associated with a long duration of remissions. Conclusion In islet antibody-positive Type 1 DM, normal body weight was the strongest factor for entering remission, whilst a low number of islet antibodies was of importance for the duration.
- Subjects
SWEDEN; DIABETES; ENDOCRINE diseases; HORMONES; HYPOGLYCEMIC agents; INSULIN; BLOOD plasma; IMMUNOGLOBULINS
- Publication
Diabetic Medicine, 2004, Vol 21, Issue 5, p447
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1111/j.1464-5491.2004.01175.x