We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Isoproterenol-induced myocardial injury resulting in altered S100A4 and S100A11 protein expression in the rat.
- Authors
Murao, Shinichi; Inamoto, Shinya; Yokoyama, Mitsuhiro; Kitazawa, Sohei; Maeda, Sakan
- Abstract
S-100 proteins (S100) are characterized by calcium-binding ability with two structural EF hands. Several S100 are expressed in cardiomyocytes and thought to play a crucial role in calcium signaling. To examine whether the expression of S100 is a response to detectable myocardial damage or regeneration, we investigated, immunohistochemically, the expression of S100A4 and S100A11 in the isoproterenol (ISP)-treated rat heart. Definite expression of S100A4 and S100A11 was demonstrated in normal cardiomyocytes, and their staining patterns were enhanced in the ISP-treated rat heart, suggesting the possible involvement of S1–A4 and S100A11 in ISP-induced myocardial damage.
- Subjects
CARDIAC hypertrophy; ISOPROTERENOL; CALCIUM-binding protein genes; GENE expression; RAT physiology; DRUG side effects
- Publication
Pathology International, 2000, Vol 50, Issue 6, p480
- ISSN
1320-5463
- Publication type
Article