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- Title
Management of Adult Patients with Immune Thrombocytopenia (ITP): A Review on Current Guidance and Experience from Clinical Practice.
- Authors
Song, Fei; Al-Samkari, Hanny
- Abstract
Immune thrombocytopenia (ITP) is an autoimmune process resulting in increased destruction and inadequate production of platelets that can result in bleeding, fatigue, and reduced health-related quality of life. While treatment is not required for many patients with ITP, the occurrence of bleeding manifestations, severe thrombocytopenia, and requirement for invasive procedures are among the reasons necessitating initiation of therapy. Corticosteroids, intravenous immunoglobulin, and anti-RhD immune globulin are typical first-line and rescue treatments, but these agents typically do not result in a durable remission in adult patients. Most patients requiring treatment therefore require subsequent line therapies, such as thrombopoietin receptor agonists (TPO-RAs), rituximab, fostamatinib, splenectomy, or a number of other immunosuppressive agents. In this focused review, we discuss management of adult ITP in the acute and chronic settings.
- Subjects
THROMBOPOIETIN receptors; ADULTS; QUALITY of life; IMMUNOSUPPRESSIVE agents; IDIOPATHIC thrombocytopenic purpura; AUTOIMMUNITY; CANCER fatigue
- Publication
Journal of Blood Medicine, 2021, Vol 12, p653
- ISSN
1179-2736
- Publication type
Article
- DOI
10.2147/JBM.S259101