We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Regulation of cell lineage specification by the retinoblastoma tumor suppressor.
- Authors
Skapek, S X; Pan, Y-R; Lee, E Y-H P
- Abstract
Early studies of the retinoblastoma gene (RB) have uncovered its critical role as a regulator of the G1/S cell cycle phase progression. Surprisingly, genetic approaches in mammals and nematodes have also shown RB controls cell lineage specification and aspects of differentiation. The RB gene product accomplishes this by diverse mechanisms such as by interacting with tissue-specific transcription factors, enhancing RNA interference, and modifying chromatin structure. We review recent studies uncovering novel mechanisms by which RB works in several cell lineages and we provide perspectives on how these new findings might relate to RB tumor suppression.Oncogene (2006) 25, 5268–5276. doi:10.1038/sj.onc.1209710
- Subjects
RETINOBLASTOMA; CELL cycle; TUMORS; CELL lines; MAMMALS; NEMATODES
- Publication
Oncogene, 2006, Vol 25, Issue 38, p5268
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/sj.onc.1209710