We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Surface-Enhanced Raman Spectroscopy of Benzylpenicillin Using Silver Nanocrystals Modified with Moroccan Plant Extracts.
- Authors
Fernine, Yasmine; Martins, Natércia C. T.; Taleb, Mustapha; Trindade, Tito
- Abstract
Green chemical routes for the synthesis of colloidal metal nanocrystals have been of great interest, namely in the context of nanosciences associated with biological applications. Among these methods, the synthesis of metal colloids using medicinal plant extracts originates nanocrystals having surfaces modified with chemical compounds of biological origin, which can be further explored in association with conventional pharmaceutics. In this context, the development of spectroscopic methods that seeks for understanding the potential benefits of using formulations that contain natural compounds and metal nanoparticles with therapeutic properties is of relevance. This research describes the chemical synthesis of silver colloids via the reduction of Ag(I) in the presence of distinct aqueous plant extracts. The selected extracts were obtained from Moroccan plants that have been used in traditional therapeutic practices over the centuries. The method led to stable colloids comprising polydispersed Ag nanocrystals that show surface-enhanced Raman scattering (SERS) activity. As an illustrative scenario, these colloids have been applied to the SERS detection of the natural β-lactam antibiotic benzylpenicillin, also known as penicillin G (PG). Our results indicate that all the Ag colloids tested with the different plant extracts are SERS-active for PG without showing detrimental interference from chemical adsorbates originated from the extracts. Therefore, this spectroscopic method can be further explored for monitoring nanoformulations of pharmaceuticals and metal colloids obtained using biological synthesis.
- Subjects
SERS spectroscopy; PLANT extracts; NANOCRYSTALS; PENICILLIN G; COLLOID synthesis; BIOSYNTHESIS; METAL nanoparticles
- Publication
Crystals (2073-4352), 2023, Vol 13, Issue 7, p1105
- ISSN
2073-4352
- Publication type
Article
- DOI
10.3390/cryst13071105