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- Title
Middle Cerebral Artery Occlusion in Wistar and Fischer-344 Rats: Functional and Morphological Assessment of the Model.
- Authors
Herz, Richard C G; Jonker, Marcel; Verheul, Hieronymus B; Hillen, Berend; Versteeg, Dirk H G; de Wildt, Dick J
- Abstract
AbstractCerebral infarction volume after occlusion of a short proximal segment of the middle cerebral artery (MCA) is reported to be different in Wistar compared to Fischer-344 (F344) rats, in both size and variability. Knowledge about the cause of these differences might enable us to explain and perhaps reduce the variation in infarct volume and create a reproducible model of focal cerebral ischemia in the rat. We investigated in Wistar and F344 rats both the effect of occlusion of a long proximal MCA segment on cerebral infarction volume, visualized by magnetic resonance imaging and histology, and the morphology of the major cerebral arteries. Occlusion of a long proximal MCA segment resulted in a striatal and a small cortical infarction in Wistar and a striatal and sizable cortical infarction in F344 rats (as is the case after occlusion of a short proximal MCA segment). In Wistar rats, however, occlusion of a long proximal MCA segment strongly reduced the variability in infarction volume in comparison to occlusion of a small proximal MCA segment. Analysis of the morphology of the major cerebral arteries showed a significantly higher number of proximal side branches of the long proximal MCA segment in Wistar rats than in F344 rats. We conclude that after short-segment proximal MCA occlusion, extreme variability in cerebral infarction volume in Wistar rats compared to F344 rats may be attributable to a significantly greater number of proximal MCA side branches in Wistar rats than F344 rats.
- Publication
Journal of Cerebral Blood Flow & Metabolism, 1996, Vol 16, Issue 2, p296
- ISSN
0271-678X
- Publication type
Article
- DOI
10.1097/00004647-199603000-00015