We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Endoscopic and Immunohistochemical Characteristics of Gastric Cancer with versus without <bold><italic>Helicobacter Pylori</italic></bold> Eradication.
- Authors
Kodama, Masaaki; Okimoto, Tadayoshi; Mizukami, Kazuhiro; Abe, Hisanori; Ogawa, Ryo; Okamoto, Kazuhisa; Shuto, Mitsutaka; Matsunari, Osamu; Hirashita, Yuka; Sato, Ryugo; Abe, Takashi; Nagai, Takayuki; Arita, Tsuyoshi; Murakami, Kazunari
- Abstract
<bold><italic>Background/Aims:</italic></bold> The rate of gastric cancer (GC) after <italic>Helicobacter pylori</italic> eradication has gradually increased; therefore, we investigate the clinicopathological features of GC following eradication in comparison with those of GC with <italic>H. pylori</italic> infection. <bold><italic>Methods:</italic></bold> This study included 50 subjects with GC after eradication (GCE) and 151 patients with GC with <italic>H. pylori</italic> infection (GCI). Clinicopathological factors were assessed. The manifestation of GC was further evaluated using immunohistochemical analysis and in situ hybridization. <bold><italic>Results:</italic></bold> Macroscopic analysis revealed a significantly higher ratio of depressed type /elevated type in the GCE compared with the GCI (30/19 vs. 61/77, <italic>p</italic> = 0.041). The gastric phenotype was more common in the GCE compared with the GCI, and the proportion of CDX2-positive cases was lower in the GCE (8 out of 18; 44.4%) compared with the GCI (18 out of 19; 94.7%; <italic>p</italic> = 0.00082). Ki-67 labeling index was significantly lower in the GCE (32.03 ± 22.15) compared with the GCI (79.20 ± 14.87, <italic>p <</italic> 0.0001). No patient in the GCE showed evidence of Epstein-Barr virus infection. <bold><italic>Conclusion:</italic></bold> The clinicopathological characteristics of GC following <italic>H. pylori</italic> eradication differ from those of GC in patients with <italic>H. pylori</italic> infection in terms of morphology, mucin phenotype, and proliferation rate.
- Subjects
STOMACH cancer; HELICOBACTER pylori; ENDOSCOPY; HELICOBACTER; DIAGNOSIS
- Publication
Digestion, 2018, Vol 97, Issue 4, p288
- ISSN
0012-2823
- Publication type
Article
- DOI
10.1159/000485504