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- Title
Infection-resistant MRI-visible scaffolds for tissue engineering applications.
- Authors
Mahmoudi, Morteza; Mingming Zhao; Yuka Matsuura; Laurent, Sophie; Yang, Phillip C.; Bernstein, Daniel; Ruiz-Lozano, Pilar; Serpooshan, Vahid
- Abstract
Tissue engineering utilizes porous scaffolds as template to guide the new tissue growth. Clinical application of scaffolding biomaterials is hindered by implant-associated infection and impaired in vivo visibility of construct in biomedical imaging modalities. We recently demonstrated the use of a bioengineered type I collagen patch to repair damaged myocardium. By incorporating superparamagnetic iron oxide nanoparticles into this patch, here, we developed an MRI-visible scaffold. Moreover, the embedded nanoparticles impeded the growth of Salmonella bacteria in the patch. Conferring anti-infection and MRI-visible activities to the engineered scaffolds can improve their clinical outcomes and reduce the morbidity/mortality of biomaterial-based regenerative therapies.
- Subjects
MAGNETIC resonance imaging; TISSUE engineering; TISSUE scaffolds; IRON oxide nanoparticles; IN vivo studies
- Publication
BioImpacts, 2016, Vol 6, Issue 2, p111
- ISSN
2228-5652
- Publication type
Article
- DOI
10.15171/bi.2016.16