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- Title
Oxaliplatin: In Operable Colorectal Cancer.
- Authors
Keam, Susan J.; Dunn, Christopher J.; Figgitt, David P.
- Abstract
▴ Oxaliplatin is available in numerous countries for the treatment of metastatic colorectal cancer (in conjunction with fluoropyrimidine therapy). The activity of oxaliplatin in advanced disease has led to investigation of its potential in operable disease. ▴ The addition of oxaliplatin to adjuvant therapy with fluorouracil and folinic acid (FOLFOX4 regimen) is associated with a significantly greater disease-free survival at 3 years (78% vs 73%; p = 0.002), according to results of the MOSAIC (Multicenter International Study of Oxaliplatin/5FU/Leucovorin [folinic acid] in the Adjuvant Treatment of Colon Cancer) trial, a study in 2246 patients with stage II or III colon cancer. ▴ In addition, a 23% reduction in the risk of disease recurrence after surgery was seen with FOLFOX4 compared with fluorouracil/folinic acid in the MOSAIC trial. ▴ Results from several phase I/II studies suggest that the addition of oxaliplatin to preoperative radiochemotherapy may be of benefit in patients with locally advanced lower rectal cancer in terms of disease downstaging and sphincter preservation. ▴ Oxaliplatin was generally well tolerated in the MOSAIC trial and neuro- and myelotoxicity with FOLFOX4 were manageable.
- Subjects
CANCER treatment; ANTINEOPLASTIC agents; FOLIC acid; IMMUNOLOGICAL adjuvants; COLON cancer; SURGERY
- Publication
Drugs, 2005, Vol 65, Issue 1, p89
- ISSN
0012-6667
- Publication type
Article
- DOI
10.2165/00003495-200565010-00005