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- Title
Cadmium accumulation and binding characteristics in intact Sertoli/germ cell units, and associated effects on stage-specific functions in vitro: insights from a shark testis model.
- Authors
Mcclusky, Leon M.
- Abstract
The article examines the stage dependency and persistency in spermatocysts 49 h after washout of cadmium (Cd) accumulation and binding in vitro with the use of shark testis model. It mentions that testis is sensitive to Cd because of the spermatogenesis's steroid-mediated regulation, transcription of genes and high levels of DNA synthesis. The shark testis was proposed as an alternative model in order to asses the stage-specific functions in living testicular tissue and to study toxicant actions on spermatogenesis. The study concludes that the shark testis model has utility for use in screening assays of environment toxicants.
- Subjects
CADMIUM poisoning; CADMIUM; APOPTOSIS; SERTOLI cells; GERM cells; REGULATION of spermatogenesis; TOXICOLOGICAL interactions; DNA synthesis; BIOACCUMULATION
- Publication
Journal of Applied Toxicology, 2008, Vol 28, Issue 2, p112
- ISSN
0260-437X
- Publication type
Article
- DOI
10.1002/jat.1253