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- Title
Treatment of the X chromosome in mapping multiple quantitative trait loci.
- Authors
Tran, Quoc; Broman, Karl W.
- Abstract
Statistical methods to map quantitative trait loci (QTL) often neglect the X chromosome and may focus exclusively on autosomal loci. But the X chromosome often requires special treatment: sex and cross-direction covariates may need to be included to avoid spurious evidence of linkage, and the X chromosome may require a separate significance threshold. In multiple-QTL analyses, including the consideration of epistatic interactions, the X chromosome also requires special care and consideration. We extend a penalized likelihood method for multiple-QTL model selection, to appropriately handle the X chromosome. We examine its performance in simulation and by application to a large eQTL data set. The method has been implemented in the package R/qtl.
- Subjects
GENE mapping; X chromosome; BIG data
- Publication
G3: Genes | Genomes | Genetics, 2021, Vol 11, Issue 2, p1
- ISSN
2160-1836
- Publication type
Article
- DOI
10.1093/g3journal/jkab005