We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Microspinning: Local Surface Mixing via Rotation of Magnetic Microparticles for Efficient Small-Volume Bioassays.
- Authors
Kim, Su Deok; Song, Seo Woo; Oh, Dong Yoon; Lee, Amos Chungwon; Koo, Jeong Woo; Kang, Taehun; Kim, Min Chang; Lee, Changhee; Jeong, Yunjin; Jeong, Hyun Yong; Lee, Daewon; Cho, Seongkyu; Kwon, Sunghoon; Kim, Jiyun
- Abstract
The need for high-throughput screening has led to the miniaturization of the reaction volume of the chamber in bioassays. As the reactor gets smaller, surface tension dominates the gravitational or inertial force, and mixing efficiency decreases in small-scale reactions. Because passive mixing by simple diffusion in tens of microliter-scale volumes takes a long time, active mixing is needed. Here, we report an efficient micromixing method using magnetically rotating microparticles with patterned magnetization induced by magnetic nanoparticle chains. Because the microparticles have magnetization patterning due to fabrication with magnetic nanoparticle chains, the microparticles can rotate along the external rotating magnetic field, causing micromixing. We validated the reaction efficiency by comparing this micromixing method with other mixing methods such as simple diffusion and the use of a rocking shaker at various working volumes. This method has the potential to be widely utilized in suspension assay technology as an efficient mixing strategy.
- Subjects
ROTATIONAL motion; BIOLOGICAL assay; GRAVITATION; SURFACE tension; MAGNETIC nanoparticles; MAGNETIC fields
- Publication
Micromachines, 2020, Vol 11, Issue 2, p175
- ISSN
2072-666X
- Publication type
Article
- DOI
10.3390/mi11020175