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- Title
Polymorphisms in ACE1 , TMPRSS2 , IFIH1 , IFNAR2 , and TYK2 Genes Are Associated with Worse Clinical Outcomes in COVID-19.
- Authors
Dieter, Cristine; de Almeida Brondani, Leticia; Lemos, Natália Emerim; Schaeffer, Ariell Freires; Zanotto, Caroline; Ramos, Denise Taurino; Girardi, Eliandra; Pellenz, Felipe Mateus; Camargo, Joiza Lins; Moresco, Karla Suzana; da Silva, Lucas Lima; Aubin, Mariana Rauback; de Oliveira, Mayara Souza; Rech, Tatiana Helena; Canani, Luís Henrique; Gerchman, Fernando; Leitão, Cristiane Bauermann; Crispim, Daisy
- Abstract
Although advanced age, male sex, and some comorbidities impact the clinical course of COVID-19, these factors only partially explain the inter-individual variability in disease severity. Some studies have shown that genetic polymorphisms contribute to COVID-19 severity; however, the results are inconclusive. Thus, we investigated the association between polymorphisms in ACE1, ACE2, DPP9, IFIH1, IFNAR2, IFNL4, TLR3, TMPRSS2, and TYK2 and the clinical course of COVID-19. A total of 694 patients with COVID-19 were categorized as: (1) ward inpatients (moderate symptoms) or patients admitted at the intensive care unit (ICU; severe symptoms); and (2) survivors or non-survivors. In females, the rs1990760/IFIH1 T/T genotype was associated with risk of ICU admission and death. Moreover, the rs1799752/ACE1 Ins and rs12329760/TMPRSS2 T alleles were associated with risk of ICU admission. In non-white patients, the rs2236757/IFNAR2 A/A genotype was associated with risk of ICU admission, while the rs1799752/ACE1 Ins/Ins genotype, rs2236757/IFNAR2 A/A genotype, and rs12329760/TMPRSS2 T allele were associated with risk of death. Moreover, some of the analyzed polymorphisms interact in the risk of worse COVID-19 outcomes. In conclusion, this study shows an association of rs1799752/ACE1, rs1990760/IFIH1, rs2236757/IFNAR2, rs12329760/TMPRSS2, and rs2304256/TYK2 polymorphisms with worse COVID-19 outcomes, especially among female and non-white patients.
- Subjects
COVID-19; INTENSIVE care patients; TREATMENT effectiveness
- Publication
Genes, 2023, Vol 14, Issue 1, p29
- ISSN
2073-4425
- Publication type
Article
- DOI
10.3390/genes14010029