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- Title
Clinical and Prognostic Features of Essential Thrombocythemia: Comparison of 2001 WHO Versus 2008/2016 WHO Criteria in a Large Single-center Cohort.
- Authors
Chiatamone Ranieri, Sofia; Arleo, Maria Antonietta; Trasarti, Stefania; Bizzoni, Luisa; Carmosino, Ida; De Luca, Maria Lucia; Mohamed, Sara; Mariggiò, Elena; Scalzulli, Emilia; Rosati, Serena; De Benedittis, Daniela; Colafigli, Gioia; Pepe, Sara; Molica, Matteo; Scamuffa, Maria Cristina; Di Prima, Alessio; Ferretti, Antonietta; Baldacci, Emilia; Mancini, Marco; Santoro, Cristina
- Abstract
<bold>Background: </bold>According to 2008/2016 classification of the World Health Organization (WHO), a platelet (PLT) count ≥ 450 × 109/L, reduced from the previously published WHO 2001 indicated level ≥ 600 × 109/L, was considered the new PLT threshold for the diagnosis of essential thrombocythemia (ET).<bold>Patients and Methods: </bold>To validate this important diagnostic change in a setting of current clinical practice, we retrospectively analyzed clinical and hematologic features at diagnosis and during follow-up of 162 patients with ET, diagnosed in our center from January 2008 to December 2017. We subdivided patients according to PLT value at baseline into Group A (PLT ≥ 600 × 109/L) (124 patients; 76.5%) and Group B (PLT ≥ 450 × 109/L < 600 × 109/L) (38 patients; 23.5%).<bold>Results: </bold>Among clinical features, only the median value of leukocytes (P < .001) was significantly higher in Group A. Cytostatic treatment was administered in 103 patients, with a significantly higher rate in patients of group A (P < .001). After a median follow-up of 42.4 months (interquartile range, 22.1-70.6 months), 8 thrombotic events were recorded in the entire cohort, without differences between the 2 groups (P = .336). The 5-year overall survival (OS) of the entire cohort was 96.9% (95% confidence interval, 92.6%-100%), without differences between the 2 groups (P = .255).<bold>Conclusions: </bold>Our data indicate a substantial homogeneity among patients with ET regardless of the PLT count at diagnosis, thus confirming the usefulness of the 2008/2016 WHO diagnostic criteria.
- Subjects
THROMBOSIS prevention; THROMBOCYTOSIS; THROMBOSIS; WORLD Health Organization; PILOT projects; REFERENCE values; RESEARCH; PROGNOSIS; RETROSPECTIVE studies; EVALUATION research; COMPARATIVE studies; PLATELET count; LEUKOCYTE count; LONGITUDINAL method; DISEASE complications
- Publication
Clinical Lymphoma, Myeloma & Leukemia, 2021, Vol 21, Issue 4, pe328
- ISSN
2152-2650
- Publication type
journal article
- DOI
10.1016/j.clml.2020.11.003