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- Title
Clear cell urothelial carcinoma: Immunohistochemical and topographical studies are suggestive of mesonephric differentiation.
- Authors
Bateman, Justin; Wasserman, Jason K.; Flood, Trevor A.; Belanger, Eric C.; Djordjevic, Bojana; Mai, Kien T.
- Abstract
Objective: Clear cell urothelial carcinoma (CCUC) is a rare variant of urothelial carcinoma with a male predominance. Currently, the origin of this entity remains unknown. In this study, we sought to characterize the origin of CCUC based on its immunohistochemical (IHC) profile and topographical location. Methods: Nine cases of CCUC from our institution were studied with the following markers: GATA3, CK7, CK20, CK5, CD44, and PAX8. Specific location in the urinary tract was recorded. Comparisons were made to cases reported in the medical literature. Results: CCUCs exhibited reactivity for GATA3/CK7 (n=9/9) and CK20 (n=5/9), as is commonly reported in the literature. In addition, tumour cells were reactive for basal cell markers CK5/CD44 (n=8/9) and PAX8 (very focal to extensive; n=5/9). All CCUCs were located in the ureter (n=1/9), trigone (n=6/9) or in the vicinity of the trigone (n=2/9). Of the ten cases reporting tumour location in the literature, seven were in the trigone and three were in the lateral walls. Conclusions: For the first time, we demonstrate evidence of mesonephric differentiation in CCUC based on its IHC profile and topographical location. As such, CCUC appears to be an entity distinct from the conventional urothelial carcinoma and may derive from a different cell precursor.
- Publication
Canadian Journal of Pathology, 2016, Vol 8, p33
- ISSN
1918-915X
- Publication type
Article