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- Title
Ligand‐free MnBr<sub>2</sub>‐Catalyzed Chemo‐ and Stereoselective Hydroboration of Terminal Alkynes.
- Authors
Pawar, Rameshwar B.; Karmur, Mital H.; Punji, Benudhar
- Abstract
Developing simple and benign protocols for synthesizing alkenylboronates is crucial as they are synthetically valuable compounds in various organic transformations. In this work, we report a straightforward ligand‐free protocol for synthesizing alkenylboronates via atom‐economical hydroboration of alkynes with HBpin catalyzed by a manganese salt. The reaction shows a high level of chemo and regioselectivity for the terminal alkynes and exclusively produces E‐selective alkenylboronates. The hydroboration scope is vast, with the resilience of a range of synthetically beneficial functionalities, such as halides, ether, alkenyl, silyl and thiophenyl groups. This reaction proceeds through the involvement of a metal‐hydride intermediate. The developed alkenylboronate can be smoothly converted to useful C‐C, C‐N and C‐I bond‐forming reactions.
- Subjects
HYDROBORATION; ALKYNES; SILYL group; ORGANIC compounds; MANGANESE
- Publication
Chemistry - An Asian Journal, 2024, Vol 19, Issue 9, p1
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/asia.202400158