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- Title
An Open‐Air Palladium‐Catalyzed Stereoselective O‐Glycosylation of Glycals via in‐situ Generation of gem‐Disubstituted Methanols from p‐Quinone Methides.
- Authors
Azeem, Ms. Zanjila; Dubey, Ms. Shashiprabha; Islam, Mr. Sk Areful; Mandal, Pintu Kumar
- Abstract
We devised a palladium‐catalyzed α‐stereoselective glycosylation that incorporates oxygen via in‐situ generation of gem‐disubstituted methanols from p‐quinone methides to access 2,3‐unsaturated gem‐diarylmethyl O‐glycosides under open‐air atmosphere at room temperature. Advantages of this environmentally friendly strategy include the absence of additives and ligands, using water as the green source of oxygen, mildest, operationally simple, exhibiting a wide functional group tolerance, and compatibility with a variety of glycal progenitors in appreciable yields. A mechanistic study has been verified via H218O labeling, which validates that water (moisture) is a sole source of oxygen.
- Subjects
GLYCALS; METHANOL; FUNCTIONAL groups; WATER use; GLYCOSYLATION
- Publication
Chemistry - An Asian Journal, 2024, Vol 19, Issue 4, p1
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/asia.202301013