We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Metal free, one pot 1,6‐Conjugate Addition of Diol on para‐Quinone Methide followed by ipso cyclization: An Approach to Spiro 1,4‐Dioxane cyclohexadienone Derivatives.
- Authors
Gaikwad, Ramesh A.; Kamble, Sumit B.; Waghmode, Suresh B.
- Abstract
A novel one‐pot transition metal‐free and Brönsted acid mediated 1,6‐conjugate addition of bisnuleophilic diol on biselectrophilc para‐quinone methide followed by ipso cyclization assisted by NBS has been developed under mild reaction conditions, offers a new approach to synthesize spiro 1,4‐dioxane cyclohexadienone derivatives. This strategy features broad substrate scope of p‐QMs with high functional group tolerance and good yields of spirocyclic scaffolds (60–92 %). N‐Bromo succinimide an important role in an ipso spirocyclization with high efficiency.
- Subjects
RING formation (Chemistry); GLYCOLS; FUNCTIONAL groups; SUCCINIMIDES; METALS; POLYURETHANE elastomers
- Publication
Chemistry - An Asian Journal, 2022, Vol 17, Issue 24, p1
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/asia.202200931