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- Title
Effects of Long Dan Xie Gan on Hepatic Antioxidant Capacity in Ducklings with Aflatoxin B<sub>1</sub> Toxicity.
- Authors
Dayou Shi; Shenquan Liao; Rongsheng Su; Yizhou Chen; Hong Wu; Zhaoxin Tang; Shining Guo
- Abstract
Aflatoxins (especially Aflatoxin B1) contaminate human and animal foods and cause reduced productivity, suppressed immune function, reduced reproductive ability and liver damage. The objective of this randomized, controlled study was to investigate the influence of the Chinese herbal medicine Long Dan Xie Gan (LDXG) on hepatic antioxidant capacity in ducklings administrated AFB1. Ninety 7-day-old ducklings were randomly divided into three groups (Groups I-III) containing 30 birds each. Group I was a control group. Group II was administered AFB1 (0.1 mg/kg body weight) orally for 21 days. Group III was administered AFB1 (0.1 mg/kg body weight) orally plus LDXG (as 2% of the feed) for 21 days. On the 7th, 14th and 21st days of treatment, 10 ducklings (5 males and 5 females) were randomly selected from each group, euthanized and 1 gram of liver was removed. The activity of hepatic superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and glutathione reductase (GR) in Group II (AFB1 only) ducklings was significantly decreased (p<0.01) and the levels of hepatic malondialdehyde (MDA) significantly increased (p<0.01), when compared to Group I (no AFB1 or LDXG) showing the adverse effects of the AFB1. The activity of hepatic SOD, CAT, GSH-Px and GR was significantly higher (p<0.05) and MDA significantly lower (p<0.05) in Group III (AFB1 + LDXG) compared to Group II (AFB1 alone) indicating antioxidant effects of LDXG. The AFB1 impairs hepatic antioxidant capacity, but LDXG significantly ameliorated the negative effects of AFB1 and may be a useful antioxidant supplement to duckling feed sources.
- Subjects
DUCKLINGS; AFLATOXINS; HERBAL medicine; CHINESE medicine; ANTIOXIDANTS
- Publication
American Journal of Traditional Chinese Veterinary Medicine, 2013, Vol 8, Issue 1, p31
- ISSN
1945-7677
- Publication type
Article