The authors respond on comments about their Vitaminc C, Hydrocortisone and Thiamine in Patients With Septic Shock (VITAMINS) trial. Topics discussed include the disappointing overall results of the effects of high-dose vitamin C, thiamine and steroids in patients with sepsis, lack of evidence for overall survival benefits and the disadvantages of having unsuited Physicians Orders for Life-Sustaining Treatment (POLST) form.