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- Title
Photodynamic Therapy for Actinic Keratoses: A Randomized Prospective Non-sponsored Cost-effectiveness Study of Daylightmediated Treatment Compared with Light-emitting Diode Treatment.
- Authors
NEITTAANMÄKI-PERTTU, Noora; GRÖNROOS, Mari; KARPPINEN, Toni T.; SNELLMAN, Erna; RISSANEN, Pekka
- Abstract
Daylight-mediated photodynamic therapy (DL-PDT) is considered as effective as conventional PDT using artificial light (light-emitting diode (LED)-PDT) for treatment of actinic keratoses (AK). This randomized prospective non-sponsored study assessed the cost-effectiveness of DL-PDT compared with LED-PDT. Seventy patients with 210 AKs were randomized to DL-PDT or LED-PDT groups. Effectiveness was assessed at 6 months. The costs included societal costs and private costs, including the time patients spent in treatment. Results are presented as incremental cost-effectiveness ratio (ICER). The total costs per patient were significantly lower for DL-PDT (€132) compared with LED-PDT (€170), giving a cost saving of €38 (p = 0.022). The estimated probabilities for patients' complete response were 0.429 for DL-PDT and 0.686 for LED-PDT; a difference in probability of being healed of 0.257. ICER showed a monetary gain of €147 per unit of effectiveness lost. DL-PDT is less costly and less effective than LED-PDT. In terms of cost-effectiveness analysis, DL-PDT provides lower value for money compared with LED-PDT.
- Subjects
KERATOSIS; PHOTODYNAMIC therapy; LIGHT emitting diodes; CLINICAL trials; COST effectiveness; MEDICAL care costs; THERAPEUTICS
- Publication
Acta Dermato-Venereologica, 2016, Vol 96, Issue 2, p241
- ISSN
0001-5555
- Publication type
Article
- DOI
10.2340/00015555-2205