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- Title
Systemically Elevated Th1-, Th2- and Th17-associated Chemokines in Psoriasis Vulgaris Before and After Ultraviolet B Treatment.
- Authors
EKMAN, Anna-Karin; SIGURDARDOTTIR, Gunnthorunn; CARLSTRÖM, Maria; KARTUL, Natalja; JENMALM, Maria C.; ENERBÄCK, Charlotta
- Abstract
Chemokines may contribute to the systemic inflammation that is linked to the increased risk of co-morbidities in patients with psoriasis. The aim of this study was to investigate circulating chemokines in patients with psoriasis and their relationship to disease severity. Analysis of plasma levels of chemokines in patients with psoriasis before narrowband ultraviolet B (UVB) therapy revealed increased expression of Th1-associated CXCL9 and -10, Th2-associated CCL17 and CCL22, and Th17-associated CCL20. CCL20 correlated with disease severity. UVB therapy reduced skin symptoms, but did not affect the chemokine levels in plasma. Anti-CD3 and anti-CD28- mediated activation of peripheral blood mononuclear cells (PBMCs) caused a higher secretion of Th2 cytokine interleukin (IL)-13 by PBMCs from patients with psoriasis than from healthy controls. The sustained high expression of inflammatory chemokines is a potential link to systemic inflammation in psoriasis. UVB therapy may be a more effective treatment of local rather than systemic inflammation.
- Subjects
CHEMOKINES; PSORIASIS; THERAPEUTIC use of ultraviolet radiation; COMORBIDITY; SKIN diseases
- Publication
Acta Dermato-Venereologica, 2013, Vol 93, Issue 5, p525
- ISSN
0001-5555
- Publication type
Article
- DOI
10.2340/00015555-1545