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- Title
The relationship between low thiol levels and major adverse cardiovascular events after primary percutaneous coronary intervention in patients with STEMI.
- Authors
Akkuş, Oğuz; Topuz, Mustafa; Koca, Hasan; Harbalioğlu, Hazar; Kaypaklı, Onur; Kaplan, Mehmet; Şen, Ömer; Bulut, Atilla; Çelik, Hakim; Erel, Özcan; Gür, Mustafa
- Abstract
Objective: The aim of this study was to investigate whether low thiol levels are associated with peri-procedural factors during primary percutaneous coronary intervention (pPCI) upon admission with ST-segment elevation myocardial infarction (STEMI), and the prognostic value at 6-month follow-up. Methods: A total of 241 consecutive acute STEMI patients who underwent pPCI and a control group of 67 individuals with a normal coronary angiography were enrolled in the study. Results: While age, contrast-induced nephropathy, N-terminal prohormone of brain natriuretic peptide (NT-proBNP), stent length, and creatinine were related to native thiol, NT-proBNP, contrast-induced nephropathy, and creatinine were related to total thiol. NT-proBNP was also related to the disulphide level. The left ventricular ejection fraction (LVEF) and the levels of native thiol, total thiol, low-density lipoprotein, and serum albumin were found to be independent predictors of major adverse cardiovascular events (MACEs) during 6 months of follow-up. Conclusion: Initial lower native thiol, total thiol, LVEF, LDL, and serum albumin may be used to identify patients with an increased long-term risk of unfavorable cardiac events in case of STEMI.
- Publication
Archives of the Turkish Society of Cardiology / Türk Kardiyoloji Derneği Arşivi, 2018, Vol 46, Issue 4, p248
- ISSN
1016-5169
- Publication type
Article
- DOI
10.5543/tkda.2018.82668