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- Title
Ocular vascular changes in relatives at high genetic risk for developing Alzheimer's disease: foveal avascular zone and choroidal thickness.
- Authors
López‐Cuenca, Inés; Salobrar‐Garcia, Elena; Alcántara‐Rey, Celia; Elvira‐Hurtado, Lorena; Fernández‐Albarral, José A.; Rojas, P.; Isabel Ramirez, Ana; Salazar, J.J.; Barabash, Ana; Manuel Ramirez, Jose; de Hoz, Rosa
- Abstract
Purpose: Alzheimer's disease is the most common cause of dementia. In addition to the age,a family history (FH+) of AD and ɛ4 allele of the ApoE gene are the main genetic risk factors for developing the disease. However, ɛ4 allele of ApoE plays a protective role in age‐related macular degeneration. In both pathologies vascular changes have been reported in the retina and the choroid. The aim of this study was analyzed ocular vascular changes in subject with high genetic risks for developing AD. Methods: A complete eye examination was carried out in 184 cognitively healthy subjects. We analyzed the choroidal thickness using optical coherence tomography (OCT) and the foveal avascular zone (FAZ) using OCT‐angiography (OCTA) and compared the results with ApoE gene expression, AD FH+, and the presence or absence of hard drusen (HD). Results: Choroidal thickness was statistically significantly different (p < 0.05) in the (FH‐, ɛ4‐, HD+) group compared with: (i) both the (FH‐, ɛ4‐, HD‐) and the (FH+, ɛ4+, HD+) groups in the superior and inferior points at 1500 μm, and (ii) the (FH+, ɛ4‐, HD+) group in the superior point at 1500 μm, There were statistically significant differences (p < 0.05) in the superficial FAZ between the (FH+, ɛ4‐, HD+) group and i) the (FH+, ɛ4‐, HD‐) group and ii) the (FH+, ɛ4+, HD‐) group. Conclusions: In conclusion, ocular vascular changes have not yet been found in participants at genetic risk of developing AD; however, subjects without genetic risk of AD who have HD should be followed for their evolution.
- Subjects
DISEASE risk factors; CHOROID; APOLIPOPROTEIN E4; POLYPOIDAL choroidal vasculopathy; MACULAR degeneration; OPTICAL coherence tomography; ALZHEIMER'S disease; AMYLOID plaque
- Publication
Acta Ophthalmologica (1755375X), 2022, Vol 100, pN.PAG
- ISSN
1755-375X
- Publication type
Abstract
- DOI
10.1111/j.1755-3768.2022.194