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- Title
Ocular adnexal lymphoma and Helicobacter pylori gastric infection.
- Authors
DECAUDIN, D; FERRONI, A; VINCENT‐SALOMON, A; VALIDIRE, P; DE CREMOUX, P; PLANCHER, C; ASSELAIN, B; GIRODET, J; MAL, F; BROUSSE, N; DENDALE, R; LUMBROSO‐LE ROUIC, L; HERMINE, O; LECUIT, M
- Abstract
Purpose There is a causal association between Helicobacter pylori (Hp) gastric infection and the development of gastric MALT lymphoma. In contrast, the link between Hp gastric infection and the development of extra‐gastric lymphoma has not been thoroughly investigated. We therefore studied the prevalence of gastric Hp infection at initial diagnosis of ophthalmologic and non‐ophthalmologic extra‐gastric lymphoma patients. Methods Three cohorts of patients were studied: a first one of 83 patients with OAL, a second one of 101 patients with extra‐ophthalmologic extra‐gastric lymphoma, and a third one of 156 control individuals (control) without malignant lymphoma. Gastric Hp infection was investigated by histopathological analysis and Hp‐specific PCR assay on gastric biopsy tissue samples. Results We found gastric Hp infection in 37 OAL patients (45%), in 25 extra‐ophthalmologic extra‐gastric lymphoma cases (25%), and in 18 controls individuals (12%) (p<0.0001 OAL/C and p<0.01 OAL/extra‐OAL cases). Gastritis was found in 51% and 9% of Hp‐positive and Hp‐negative lymphoma patients, respectively (p<10‐4). Gastric Hp infection only correlated with MALT/LPL lymphoma (p = 0.03). Conclusion There is a significant association between gastric Hp infection and MALT/LPL OAL. This suggests a novel mechanism of indirect infection‐associated lymphomagenesis whereby chronic local antigen stimulation would lead to the emergence of ectopic B‐cell lymphoma.
- Subjects
HELICOBACTER pylori infections; LYMPHOMAS; MUCOSA-associated lymphoid tissue lymphoma; HELICOBACTER pylori
- Publication
Acta Ophthalmologica (1755375X), 2010, Vol 88, p0
- ISSN
1755-375X
- Publication type
Article
- DOI
10.1111/j.1755-3768.2010.4166.x