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- Title
Overexpression of SCUBE2 Inhibits Proliferation, Migration, and Invasion in Glioma Cells.
- Authors
Erkun Guo; Hongjiang Liu; Xiaopeng Liu
- Abstract
Signal peptide CUB EGF-like domain-containing protein 2 (SCUBE2), a member of the SCUBE family of proteins, was recently found to play an important role in cancer development. However, little is known regarding its biological function in glioma. In the present study, we investigated the effect of SCUBE2 on glioma and explored its relevant mechanisms. The study showed that SCUBE2 had a low expression in glioma tissue and cell lines. SCUBE2 overexpression inhibited glioma cell proliferation in vitro and in vivo as well as suppressed glioma cell migration and invasion in vitro. Furthermore, we found that the Sonic hedgehog (Shh) signaling pathway was involved in the inhibitory effect of SCUBE2 overexpression on glioma cells. In light of the results obtained from our study, SCUBE2 may be regarded as a potential therapeutic target for glioma.
- Subjects
IN vitro studies; SIGNAL peptides; GLIOMAS; NERVOUS system tumors; DISEASES; GENETICS; HEDGEHOG signaling proteins
- Publication
Oncology Research, 2017, Vol 25, Issue 3, p437
- ISSN
0965-0407
- Publication type
Article
- DOI
10.3727/096504016X14747335734344