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- Title
Tumour cryoablation combined with palliative bypass surgery in the treatment of unresectable pancreatic cancer: a retrospective study of 142 patients.
- Authors
Li J; Chen X; Yang H; Wang X; Yuan D; Zeng Y; Wen T; Yan L; Li B
- Abstract
Background Although cryosurgery has been proved to be an effective treatment to extend the survival time of unresectable liver cancer patients and improve their quality of life, few surgeons actually treat unresectable pancreatic cancer with this method because of its safety risks. This study aims to evaluate the safety and efficacy of cryosurgical ablation in the treatment for unresectable pancreatic cancer. Methods A retrospective study was conducted on 142 patients who underwent palliative bypass with cryoablation (PBC group: 68) or without cryoablation (PB group: 74) for unresectable pancreatic cancer from 1995 to 2002. The morbidity and 5 year survival rates of the two groups were compared. Carbohydrate antigen 19-9 (CA19-9) level and tumour size were evaluated in PBC group. Results There was no significant difference in the rate of overall complications between the two groups (p=0.809), except for a higher delayed gastric emptying rate observed in the PBC group (36.8% vs 16.2%, p=0.005). In the PBC group, the median preoperative CA19-9 concentration decreased from 690U/ml to 56U/ml (p=0.000). CT scan results of 55 patients indicated that tumour mass shrinkage occurred in 36 of them, from 4.3cm to 2.4cm (pre-ablation to 3months after ablation). Kaplan-Meier analysis showed no significant difference in 5year survival rates between the two groups (p=0.124). Conclusions Cryosurgery combined with palliative bypass surgery can be considered a safe and effective treatment for unresectable pancreatic cancer. Though this technique remains only palliative, it may be further employed to improve advanced stage pancreatic cancer.
- Publication
Postgraduate Medical Journal, 2011, Vol 87, Issue 1024, p89
- ISSN
0032-5473
- Publication type
Journal Article