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- Title
Switchable Bifunctional Stimuli-Triggered Poly- N-Isopropylacrylamide/DNA Hydrogels.
- Authors
Guo, Weiwei; Lu, Chun-Hua; Qi, Xiu-Juan; Orbach, Ron; Fadeev, Michael; Yang, Huang-Hao; Willner, Itamar
- Abstract
DNA-tethered poly- N-isopropylacrylamide copolymer chains, pNIPAM, that include nucleic acid tethers have been synthesized. They are capable of inducing pH-stimulated crosslinking of the chains by i-motif structures or to be bridged by Ag+ ions to form duplexes. The solutions of pNIPAM chains undergo crosslinking at pH 5.2 or in the presence of Ag+ ions to form hydrogels. The hydrogels reveal switchable hydrogel-to-solution transitions by the reversible crosslinking of the chains at pH 5.2 and the separation of the crosslinking units at pH 7.5, or by the Ag+ ion-stimulated crosslinking of the chains and the reverse dissolution of the hydrogel by the cysteamine-induced elimination of the Ag+ ions. The DNA-crosslinked hydrogels are thermosensitive and undergo reversible temperature-controlled hydrogel-to-solid transitions. The solid pNIPAM matrices are protected against the OH− or cysteamine-stimulated dissociation to the respective polymer solutions.
- Subjects
BIFUNCTIONAL catalysis; DNA; HYDROGELS; IONS; CROSSLINKING (Polymerization); DISSOLUTION (Chemistry); CYSTEAMINE
- Publication
Angewandte Chemie International Edition, 2014, Vol 53, Issue 38, p10134
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201405692