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- Title
Effects of traditional Chinese herbal medicine in patients with diabetic kidney disease: study protocol for a randomized controlled trial.
- Authors
Wang, Mengdi; Wang, Zhen; Zhou, Jingwei; Sun, Weiwei; Wang, Ying; Han, Mei; Yang, Hanwen; Liu, Wei Jing; Wang, Yaoxian
- Abstract
<bold>Background: </bold>Diabetic kidney disease (DKD) is a major microvascular complication of diabetes mellitus and the primary cause of end-stage renal disease. Existing therapies for DKD are not sufficiently effective. We report the protocol of a pragmatic randomized controlled trial of the use of traditional Chinese herbal medicine to treat patients with DKD.<bold>Methods/design: </bold>This will be a multicenter randomized controlled trial. A total of 266 patients with DKD (106 with early stage, 80 with middle-stage, and 80 with advanced-stage disease) with an estimated glomerular filtration rate (eGFR) ≥ 30 mL/min/1.73m2will be included. Participants with DKD of each stage will be randomly allocated at a 1:1 ratio to either the experimental group, which will receive Xiaozhen formula and basic treatment, or the control group, which will receive basic treatment only. The study duration will be 24 weeks. The primary outcome will be urinary microalbumin excretion rate for early stage DKD, 24-h urinary protein for middle-stage DKD, and eGFR for advanced-stage DKD. Adverse events will also be evaluated. Data for all outcome indicators will be collected at baseline and weeks 4, 12, and 24.<bold>Discussion: </bold>This study will provide evidence of the effectiveness and safety of traditional Chinese herbal medicine in treating patients with DKD.<bold>Trial Registration: </bold>Chinese Clinical Trials Registry: ChiCTR-IOR-16010072 . Registered on 2 December 2016.
- Subjects
DIABETIC nephropathies; EXCRETION; GLOMERULAR filtration rate; RANDOMIZED controlled trials; CHINESE medicine
- Publication
Trials, 2018, Vol 19, Issue 1, pN.PAG
- ISSN
1745-6215
- Publication type
journal article
- DOI
10.1186/s13063-018-2749-6